Biological ActivityTechnical DataSolubilityCalculatorsDatasheetsReferences
MDM2 villain (IC50 = Ninety days nM); halts that MDM2-p53 connection.
Working enantiomer associated with Nutlin-3 (Cat. Hardly any. 3984). Induces manifestation intended for P53 licensed genetics. Inhibits cancerous growth development in vivo >98% around prostate cancers and also osteosarcoma cancer tumor devices. Antiproliferative.
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|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Keep Solutions
The actual immediately after information can be structured in your unit molecular extra fat 581.49.
Portion specified molecular dumbbells could range coming from order that will portion anticipated so that you can any level regarding hydration, which inturn will probably impact the actual solvent volumes required for you to make stock solutions.
|Concentration Or Mentos write-up essay Amount And Mass||1 mg||5 mg||10 mg|
|1 mM||1.72 mL||8.6 mL||17.2 mL|
|5 mM||0.34 mL||1.72 mL||3.44 mL|
|10 mM||0.17 mL||0.86 mL||1.72 mL|
|50 mM||0.03 mL||0.17 mL||0.34 mL|
References are actually periodicals this guidance your inbreed task connected with that product.
Tovaret al nutlin 3a functionality essay Small-molecule MDM2 antagonists discuss aberrant p53 signaling through cancer: benefits to get healing.
Proc.Natl.Acad.Sci.USA. 103 1888 PMID: 16443686
Vassilevet al (2004) In vivo account activation connected with your p53 walkway by just small-molecule antagonists about MDM2. Development 303 844 PMID: 14704432
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