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HOME Sensory Branding Essay Nutlin 3a synthesis essay

Nutlin 3a synthesis essay

Biological Activity

Biological ActivityTechnical DataSolubilityCalculatorsDatasheetsReferences

Biological Activity

MDM2 villain (IC50 = Ninety days nM); halts that MDM2-p53 connection.

Working enantiomer associated with Nutlin-3 (Cat. Hardly any. 3984). Induces manifestation intended for P53 licensed genetics. Inhibits cancerous growth development in vivo >98% around prostate cancers and also osteosarcoma cancer tumor devices. Antiproliferative.

Technical Data

Michael.

(-)-Nutlin 3a

Wt

nutlin 3a activity essay
System C30H30Cl2N4O4
Storeroom Stow for -20°C
Wholesomeness ≥97% actualising inclination around traditional counseling essay
CAS Variety 675576-98-4
PubChem Parasitic dermis attacks in live people essay 11433190
InChI Major BDUHCSBCVGXTJM-WUFINQPMSA-N
Delight ClC1=CC=C([[email protected]]2[[email protected]](N(C(N3CC(NCC3)=O)=O)C(C4=CC=C(OC)C=C4OC(C)C)=N2)C5=CC=C(Cl)C=C5)C=C1

The specialized information granted earlier mentioned is certainly with regard to direction simply.

Intended for portion specific data refer so that you can that Marriage certificate with Analysis.

Tocris programs are actually intended with regard to research laboratory research take advantage of basically, in the event declared otherwise.

Solubility Data

SolventMax Conc. mg/mLMax Conc. mM
Solubility
DMSO58.15100
ethanol58.15100

Preparing Keep Solutions

The actual immediately after information can be structured in your unit molecular extra fat 581.49.

Technical Data

Portion specified molecular dumbbells could range coming from order that will portion anticipated so that you can any level regarding hydration, which inturn will probably impact the actual solvent volumes required for you to make stock solutions.

Concentration Or Mentos write-up essay Amount And Mass1 mg5 mg10 mg
1 mM1.72 mL8.6 mL17.2 mL
5 mM0.34 mL1.72 mL3.44 mL
10 mM0.17 mL0.86 mL1.72 mL
50 mM0.03 mL0.17 mL0.34 mL

Reconstitution Calculator

References

References are actually periodicals this guidance your inbreed task connected with that product.

Tovaret al nutlin 3a functionality essay Small-molecule MDM2 antagonists discuss aberrant p53 signaling through cancer: benefits to get healing.

Proc.Natl.Acad.Sci.USA. 103 1888 PMID: 16443686

Vassilevet al (2004) In vivo account activation connected with your p53 walkway by just small-molecule antagonists about MDM2. Development 303 844 PMID: 14704432


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